But why not do the MS prevention study as part of a national registry study after an EBV vaccine is licensed and offered as part of the national vaccine programme; say for the prevention of infectious mononucleosis? By doing this you can look at the impact of EBV vaccination on not only the incidence of MS, but also on other EBV-associated diseases (cancers, SLE, primary biliary cirrhosis, Sjogren's syndrome, rheumatoid arthritis, etc.)?
Agree looking at multiple outcomes is the way forward! Proper registry obviously has some weakness vs randomised trials but agree also more likely viable. Main concern would be that if it's optional then the vaccine group may be enriched for people with strong family history of autoimmune disease (and so may mask an effect of vaccine)
I think every individual diagnosed with MS, should be tested their vitamin D levels. I feel very low vitamin D reactivates the EBV. .
Has anyone looked at that. My daughter's vitamin D was 17 nmol on diagnosis and the Neurologist that diagnosed her, did not look into her vitamin D levels.
Her vitamin D levels generally over 110 nmol now,
and her treatment with Mavenclad has been very effective. I will be very interested in Dr G's comment.
Dr Jacobs, nice post.
But why not do the MS prevention study as part of a national registry study after an EBV vaccine is licensed and offered as part of the national vaccine programme; say for the prevention of infectious mononucleosis? By doing this you can look at the impact of EBV vaccination on not only the incidence of MS, but also on other EBV-associated diseases (cancers, SLE, primary biliary cirrhosis, Sjogren's syndrome, rheumatoid arthritis, etc.)?
Agree looking at multiple outcomes is the way forward! Proper registry obviously has some weakness vs randomised trials but agree also more likely viable. Main concern would be that if it's optional then the vaccine group may be enriched for people with strong family history of autoimmune disease (and so may mask an effect of vaccine)
I think every individual diagnosed with MS, should be tested their vitamin D levels. I feel very low vitamin D reactivates the EBV. .
Has anyone looked at that. My daughter's vitamin D was 17 nmol on diagnosis and the Neurologist that diagnosed her, did not look into her vitamin D levels.
Her vitamin D levels generally over 110 nmol now,
and her treatment with Mavenclad has been very effective. I will be very interested in Dr G's comment.